米国の分析機器展示会 ピッツ展で LCMS-IT-TOF が受賞
PITTCON Editors'Award は，ピッツ展に展示された製品の中から注目される新製品（今回は30機種がノミネート）を，分析機器の業界紙の記者による投票で選考するものです。
Shimadzu introduces the first LCMS-ion trap-time-of-flight (LCMS-IT-TOF) mass spectrometer and wins Pittcon Editors’ Silver Award.
For the first time, a tandem MS/MS spectrometer for use with HPLC, incorporating both ion trap and time-of-flight capabilities, is available from a major instrument company. Hybrid mass spectrometers, such as Shimadzu’s new LCMS-IT-TOF instrument have been embraced by the analytical community for their unique capabilities. The combination of these two different mass spectrometry techniques results in capabilities beyond any single mass analyzing technology. Ion trap mass spectrometry allows target molecules to be selected and fragmented easily while time-of-flight MS allows for accurate mass determination.
The new instrument allows more qualitative information about a sample to be collected in a single run, thus eliminating multiple analyses and without having to split samples between multiple instruments. Now, researchers and scientists will be able to analyze new molecules to deduce structure, analyze impurities and contaminants to determine what the compounds are, and to look at metabolites and biomarkers to evaluate biological pathways. The technologies used in the LCMS-IT-TOF allow molecules to be broken up into successively smaller fragments, and the masses of those fragments to be measured accurately enough to determine the likely empirical and structural formulae. For example, several metabolites may form through the normal metabolic processes in the human body. These will generally have different masses, although portions of the metabolites’ structures may be quite similar. In this case, the new mass spectrometer can find these quickly and unambiguously. With the new LCMS-IT-TOF, it will be possible to fragment the various component peaks found in a HPLC separation to determine formulae for each and where they come from. The new instrument is expected to find uses in forensics, proteomics, drug development, and environmental chemistry.
Shimadzu incorporated a host of innovative technologies in developing this instrument, including development of new ion transfer optics, development of compressed ion introduction prior to the ion trap and better ion cooling at lower gas pressures. Shimadzu also improved mass resolving power through the use of ballistic ion ejection so the trap does not get overfilled or have difficulties with space-charge effects. Long-term mass accuracy and stability are improved with the use of temperature control of the flight tube and improvements to the dual-stage reflectron. The source design, desolvation capillary and reduced collision ion focusing Q-Array were adapted from Shimadzu’s successful single quad HPLC mass spectrometer.
The importance of the LCMS-IT-TOF instrument was recognized by the editors of industry trade publications and journals with the award of the Editors' Silver Award at Pittcon 2005. This was also the first time the instrument was shown at a major U.S. tradeshow.
The LCMS-IT-TOF mass spectrometer will change the way researchers deduce the structure of unknown compounds and contaminants. It represents a significant improvement over other mass spectrometry techniques because of the combination of high sensitivity and long-term stability of mass accuracy in an easy to use instrument for HPLC use.